Functional Genomics of Lymphoid Cancers
Room Nmb. 2031
Hongling Yuan, M.D. (Specialist)
Burcu Akman (Ph.D. student)
Esra Baytak (MSc student)
Deniz Kurşun (MSc student)
Our current research mainly focuses on the identification and characterization of novel mutations and epigenetic alterations of tumor suppressor genes or oncogenes in lymphoid cancers. Our interest mainly resides in lymphomas (e.g. follicular lymphoma) and other lymphoid cancers (e.g. multiple myeloma) which are neoplastic diseases having a high degree of genetic heterogeneity.
We frequently use next generation sequencing (NGS) based technologies (e.g. WES, RNA-Seq, targeted NGS) to generate a candidate list of aberrant genes using panels of lymphoma patient samples. We then cross-validate mutations that are identified through NGS methodologies by applying Sanger sequencing. Moreover, our studies focus on genome-wide or loci-specific methylation changes in cancer samples. Altogether, we characterize these aberrations using a combination of genetic, epigenetic and molecular biology assays. In general, our studies follow a wholistic approach which involves the cooperation of a variety interrelated biomedical disciplines such as pathology, functional genomics, and computational bioinformatics. Our eventual goal is to identify and characterize genetic and epigenetic abnormalities in individual cancer patients to translate the discoveries as personalized medicine.
Küçük lab is currently seeking highly-motivated graduate students. If interested, please contact Dr. Küçük by email: firstname.lastname@example.org
|Can Küçük’s CV
|04/15 – present||Assistant Professor of Medical Biology, Izmir International Biomedicine and Genome Institute, Izmir, Turkey.|
|11/14 – 03/15||Tübitak 2232 grantee, Dokuz Eylul University Izmir Biomedicine and Genome Center, Izmir, Turkey.|
|10/13 – 10/14||Postdoctoral Research Fellow, Department of Pathology, City of Hope Medical Center, Duarte, CA, USA.|
|10/12 – 09/13||Postdoctoral Research Associate, Department of Pathology and Microbiology, University of Nebraska Medical Center (UNMC), Omaha, NE, USA.|
|12/06 – 10/12||Ph.D. in Cancer Biology and Oncology, Cancer Research Graduate Program (CRGP), University of Nebraska Medical Center (UNMC), Omaha, NE, USA.|
|09/05 – 12/06||Graduate Research Assistant* in Development, Cell and Neurobiology, Lousiana State University Health Sciences Center (LSUHSC), New Orleans, LA, USA.|
|09/01 – 07/05||B.Sc. in Molecular Biology and Genetics, Middle East Technical University (METU), Ankara, Turkey.|
|*: Transferred to a new Ph.D. program due to Hurricane Kathrina.|
|AWARDS AND RECOGNITION
• Turkish Academy of Sciences (TÜBA)-The Young Scientists Award Programme (GEBIP), Turkey, 2017.
• XV. National Medical Biology and Genetic Congress, Young Investigator 1st Ranking Award, Turkey, 2017.
• Science Academy – Young Scientist Award (BAGEP),Turkey, 2015.
• TÜBİTAK – BİDEB 2232 Reintegration Grant, Turkey, 2014.
• American Society of Hematology (ASH) – Abstract Achievement Award, USA, 2013.
• UNMC – Graduate Studies Assistantship (Competetive renewal at 2010), USA, 2009.
• TÜBİTAK – Basic Sciences B Scholarship, Turkey, 2002.
Full list and citations: Google Scholar: Can Kucuk